DTC U0101 means that the vehicle's control module has lost communication with the TCM (Transmission Control Module). This is the brain of the transmission, which receives signals from other systems and controls gear shifting. If the communication is lost, the transmission may go into limp mode or stop working altogether.
Error U0101 is most commonly found in vehicles with automatic transmissions from manufacturers like Ford, Chevrolet, Nissan, Honda, Volkswagen (VW), Citroen, SEAT, Toyota, and Chrysler. It is especially common in models with electromechanical or robotic transmissions.